Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet (2024)

Ban, S. J., Rico, C. W., Um, I. C., & Kang, M. Y. (2012). Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet. International Journal of Molecular Sciences, 13(3), 3738-3750. https://doi.org/10.3390/ijms13033738

Ban, Su Jeong ; Rico, Catherine W. ; Um, In Chul et al. / Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet. In: International Journal of Molecular Sciences. 2012 ; Vol. 13, No. 3. pp. 3738-3750.

@article{2d93971aa8714491aa0f721eef91af55,

title = "Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet",

abstract = "The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat diet-induced hyperglycemia and oxidative stress.",

keywords = "Antioxidative effect, Glucose metabolism, High fat diet, Hydroxyethyl methylcellulose, Hydroxypropyl methylcellulose",

author = "Ban, {Su Jeong} and Rico, {Catherine W.} and Um, {In Chul} and Kang, {Mi Young}",

year = "2012",

month = mar,

doi = "10.3390/ijms13033738",

language = "English",

volume = "13",

pages = "3738--3750",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

Ban, SJ, Rico, CW, Um, IC & Kang, MY 2012, 'Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet', International Journal of Molecular Sciences, vol. 13, no. 3, pp. 3738-3750. https://doi.org/10.3390/ijms13033738

Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet. / Ban, Su Jeong; Rico, Catherine W.; Um, In Chul et al.
In: International Journal of Molecular Sciences, Vol. 13, No. 3, 03.2012, p. 3738-3750.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet

AU - Ban, Su Jeong

AU - Rico, Catherine W.

AU - Um, In Chul

AU - Kang, Mi Young

PY - 2012/3

Y1 - 2012/3

N2 - The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat diet-induced hyperglycemia and oxidative stress.

AB - The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat diet-induced hyperglycemia and oxidative stress.

KW - Antioxidative effect

KW - Glucose metabolism

KW - High fat diet

KW - Hydroxyethyl methylcellulose

KW - Hydroxypropyl methylcellulose

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U2 - 10.3390/ijms13033738

DO - 10.3390/ijms13033738

M3 - Article

C2 - 22489179

AN - SCOPUS:84858983534

SN - 1661-6596

VL - 13

SP - 3738

EP - 3750

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 3

ER -

Ban SJ, Rico CW, Um IC, Kang MY. Antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) in mice fed with a high fat diet. International Journal of Molecular Sciences. 2012 Mar;13(3):3738-3750. doi: 10.3390/ijms13033738